High-and medium molecular-weight fractions from Lignosus rhinocerus demonstrated anticancer activities against breast and lung cancer cell lines (Yap, et al., 2015). Only the medium molecular weight fraction demonstrates selectivity and targets cancer cells and not normal breast cells. The fraction was found to contain a huge composition of lectins and serine proteases.
The native lectins were difficult to separate, insufficient in quantity for further assessment. Recombinant technology was applied to clone, overexpress and purify the most abundant lectin from the mushroom.
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