1. Technology Overview
The present invention discloses a method to produce a medicament which comprises uridine content extracted from the Pleurotus giganteus (P. giganteus) mushroom for enhancing the neurite outgrowth. The method manages to produce uridine content that is able to increase the percentage of neurite-bearing cells of differentiating neuroblastoma (N2a) cells which involve in the expression of neurofilaments proteins for neurite outgrowth. The neuronal biomarkers (GAP-43, tubulin alpha 4a, and beta) in N2a cells are significantly increased and other related signalling pathways such as MEK/ERK and PI3K/Akt/mTOR pathways are activated when treated with the uridine content produced according to the method of the present invention. This highlights the potential use of the method according to the present invention to promote the neurite outgrowth by differentiating N2a cells.
- UMCIC File Number: 603/1188
- Patent: PI 2016 704044
- Patent status: Pending
- Malaysia patent: Pleurotus Giganteus Containing Uridine As A Neurotrophic Agent
- This technology is currently available for licensing and commercialisation.