A Method to Distinguish and Grade the Severity of Traumatic Brain Injury to Mild, Moderate or Severe

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1. Technology Overview

The current trend of using Glasgow Coma Scale (GCS) as a standard component to provide a prognostic scale for Traumatic Brain Injury (TBI) has become limited since the patients are under the influence of sedative medication to keep them calm. Assessing GCS by the time they arrive at the trauma unit will not be indicative of the actual conscious state.There are also chances of missing TBI as patients can appear to be normal with full GCS scores and neuroimaging tests such as CT scan or MRI may or may not show evidence of any damage. This invention refers to a unique method that is able to distinguish and grade the severity of TBI by identifying the concentration level of specific serum biomarkers associated to brain injury.


2. Technology Features and Specifications
  • Based on biological markers in blood
    • TBI can be masked by various factors such as sedatives, facial injury, alcohol consumption and low blood oxygen among others
    • Biological components responding to TBI are unaffected by these factors
    • Using said components as biological markers allows for the diagnosis of TBI where otherwise impossible
  • Assess extent of trauma
    • Biological components react in a consistent pattern to trauma
    • By assessing the increase in the markers, this invention can determine the severity of the TBI
  • Minimally-invasive
    • Only utilizes blood drawn from the patient


3. Market Opportunity and Potential Applications

Current clinical assessment for TBI may not be accurate and can be compromised by many factors (eg. Alcohol intoxication, hypotension, sedatives and etc). Furthermore, there is no available biochemical test to distinguish severity of the TBI apart from clinical assessment. This invention is able to fill that void by being able to not just determine if TBI has occurred but also the severity of it. As such, it has tremendous market potential in the medical field, especially for hospitals and emergency centers.


4. Benefits and Impacts

Benefits include being able to detect TBI and to assess the severity of it. An accurate appreciation of the severity of TBI can help to predict outcomes and rationally help to decide when the application of aggressive therapeutic interventions would be necessary.


5. Development Stage

Available for Licensing

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