A Method to Diagnose Cardiac Wall Motion Abnormality Due To Myocardial Disease

1. Technology Overview

The present invention disclosed a method to directly quantify cardiac wall motion abnormality due to focal myocardial disease using deformable motion model registration. The present invention merges tagged, cine and late-gadolinium enhanced magnetic resonance sequence to allow injury-specific division of left ventricular myocardium into several sectors for accurate motion tracking throughout the entire cycle. Using frame-to-frame non-rigid registration scheme, the simplified motion model efficiently tracks two most important motions consisting of contraction and rotation in each defined sector on short-axis tagged MR images from base to apex. The present invention allows direct reporting of contractility dysfunction based on myocardial injury into five clinical motion scoring categories including normokinesia, hypokinesia, akinesia, hyperkinesia, dyskinesia for practical clinical application in terms of diagnosis and treatment progress monitoring.

  • UMCIC File Number: 603/1204
  • Patent: PI 2016 704828
  • Patent status: Pending
  • Malaysia patent: A Method to Diagnose Cardiac Wall Motion Abnormality Due To Myocardial Disease
  • This technology is currently available for licensing and commercialisation.