Method and Apparatus for Profiling DNA Specimen

1. Technology Overview

DNA is a biological database that stores all the biological information of an individual. It is often used as an identifier as each organism has a different DNA structure. A reliable method in identifying matching DNA to individuals is crucial in areas such as forensics and paternity testing. Currently, this is achieved by comparing the length of variable sections or sequences of the genes in the DNA between individuals. However, some organisms, especially those closely-related to one another, have very similar DNA structures that make it difficult to distinguish between them without going through long, drawn out and costly processes. Conventional techniques of electrophoresis and genome sequencing are unable to demonstrate the differences between those closely related organisms. This invention serves to rectify that by introducing a cost-effective and quick method of characterising DNA based on semiconductor principles to identify and profile unknown DNA.


2. Technology Features and Specifications
  • Innovative novel technique
    • First non-biological method of characterising DNA
    • Uses electrical conductivity based on semiconductor principles
  • Consistent and unique identifiers
    • The process generates a current over voltage profile (graph)
    • Profile is unique to different organisms
    • The process will consistently generate the same profile if parameters are unchanged
    • Can be used to create a reliable database and signature profiles of organisms



3. Market Opportunity and Potential Applications

This invention has numerous strengths that capitalize on weaknesses that exist with currently used diagnosis methods. The efficacy of this method in using ratios of the biomarkers to discriminate between healthy people, patients with benign prostatic hyperplasia and prostate cancer renders it as a suitable, more reliable alternative to conventional diagnosis methods.


4. Benefits and Impacts

This invention is cost-effective and reliable. These two features are of primary importance to researchers all over the globe. The ability of this invention to distinguish between different DNA specimens will benefit researchers who are dealing with large samples and can’t afford to sequence them all. The method also enables direct realization of possible applications in terms of detection of pathogens, which may include bacteria, fungal etc. The technique generally allows a rapid and fully electronic method in pathology and diagnostics besides cancer detection, disease progression studies, forensics and others.


5. Development Stage

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